The Pistons opened the 2007 NBA Playoffs with a 4–0 victory over the Orlando Magic, their first playoff series sweep since 1990. The team advanced to face the Chicago Bulls, marking the first time that the Central Division rivals had met in the postseason since 1991. After winning the first two games by 26 and 21 points, the Pistons overcame a 19-point deficit to win Game 3, 81–74. Chicago avoided elimination by winning Games 4 and 5, but the Pistons closed out the series, 95–85, in Game 6. They advanced to the Eastern Conference Finals for the fifth consecutive time (equaling their streak from 1987–1991) - one short of the NBA record set by the Los Angeles Lakers in the 1980s. In the Eastern Conference Finals, the Pistons won games 1 and 2, but lost 4 in a row to the Cavaliers.

Following the season, the Pistons traded Carlos Delfino to the Toronto Raptors in exchange for 2009 and 2011 second-round draft picks. In the 2007 NBA Draft the Pistons selected Rodney Stuckey as the 15th overall pick and Arron Afflalo as the 27th overall pick.[8] They also re-signed Chauncey Billups to a long-term contract, as well as re-signing top prospect Amir Johnson and key reserve Antonio McDyess. This season will mark the 50th anniversary of the franchise in Detroit, so The Palace of Auburn Hills floor was given a retouch, as the 50th anniversary logo was encased on center court, and blue replaced red on the sideline, retaining red on the baseline surrounding the basket with the words "Detroit Pistons." The remainder of the court remained unchanged. This marked the first time since their first season at the Pontiac Silverdome (1978-79) that the sideline of the Pistons floor will be painted blue, as opposed to their traditional red.